Phase I Rectal Microbicide Study
Nonoxynol-9
Treatment Adherence and Compliance+20
+ Blood-Borne Infections
+ Urogenital Diseases
Prevention Study
Summary
Chemical barriers which can be controlled by the receptive partner to prevent transmission of HIV and other sexually transmitted diseases (STDs) are among the highest priorities for research and development. Advantage 24 is a contraceptive gel containing nonoxynol-9 (N-9). This study provides information on the safety of N-9 in a bioadhesive gel formulated for use by MSM during anal intercourse. Safety is assessed for both HIV-positive and HIV-negative men because HIV-positive men may be at increased risk for toxicity due to other HIV-related conditions. Participants are divided into 4 cohorts depending on their serostatus and whether they are the insertive or receptive partner. Participants apply Advantage 24 once or twice a day for 5 weeks and 4 times a day for the sixth week. Check-in visits, which include a genital exam, are performed at Weeks 1, 2, 4, 5, and 7. More complete physical evaluations, including anoscopy for receptive partners and blood tests, are performed at Weeks 3, 6, and 8.
Protocol
This section provides details of the study plan, including how the study is designed and what the study is measuring.70 patients to be enrolled
Total number of participants that the clinical trial aims to recruit.Prevention Study
Eligibility
Researchers look for people who fit a certain description, called eligibility criteria: person's general health condition or prior treatments.Male
Biological sex of participants that are eligible to enroll.Over 18 Years
Range of ages for which participants are eligible to join.Healthy volunteers allowed
If individuals who are healthy and do not have the condition being studied can participate.Conditions
Pathology
Criteria
Exclusion Criteria Co-existing Condition: Participants with the following symptoms or conditions are excluded: Positive HSV-2 serology (HIV-negative participants only). Positive syphilis by Venereal Disease Research Laboratory (VDRL) serology and Fluorescent Treponemal Antibody (FTA) or Microhemagglutination Assay (MHA). Receptive partners with the following additional symptoms or conditions are excluded: Rectal gonorrhea or chlamydia by culture. Active rectal inflammation, ulceration, or fissures. Insertive partners with the following additional symptoms or conditions are excluded: Penile or urethral irritation, rashes, or lesions. Penile or scrotal piercing. Concurrent Medication: Excluded for receptive partners: - Anticoagulant, including warfarin and heparin. Participants with the following prior conditions are excluded: Sensitivity or irritative symptoms when using N-9 or when exposed to latex. Three or more Herpes Simplex 2 Virus (HSV-2) outbreaks within 12 months prior to screening (HIV-positive participants only). One or more HSV-2 outbreaks within 6 months prior to screening (HIV-positive participants only). Receptive partners with the following additional prior conditions are excluded: Diagnosed inflammatory bowel disease, ulcerative colitis, Crohn's disease, or rectal malignancy. Diagnosed bleeding disorder, including hemophilia and thrombocytopenia. Rectal surgery including fistulectomy. Prosthetic heart valve or diagnosis of a valvular abnormality. Hemorrhoidectomy within 6 months prior to screening. Rectal burning, tenesmus, bleeding, or irritation in the week prior to screening. Diarrhea (more than 3 stools per day) in the week prior to screening. Use of rectally-inserted sex toys, practiced receptive fisting, or rectal douching in the week prior to screening. Insertive partners with the following additional prior conditions are excluded: Urethral burning or discharge in the week prior to screening. Prior Medication: Excluded for receptive partners: Use of laxatives in the week prior to screening. Participants meet the following criteria: HIV-negative or HIV-positive; participant's partner must be the same serostatus. Plan to have anal intercourse only with the study partner for the duration of the study. During all episodes in which Advantage 24 is used, one partner is exclusively insertive and the other partner is exclusively receptive. Sexual partner of at least 3 months is eligible and agrees to participate. Agree to use non-N-9 lubricant and condoms for all episodes of anal intercourse. Avoid use of Advantage 24 for purposes other than specified by the protocol. Receptive partners meet the following additional criteria: Plan to have receptive anal intercourse with the study partner with Advantage 24 applied rectally, and using N-9 lubricant and condoms, at the couple's usual frequency (at least 3 times per week). Agree to apply the specified amount of Advantage 24 daily to the rectum. Avoid use of laxatives, use of rectally-inserted sex toys, receptive fisting, and rectal douching. Insertive partners meet the following additional criteria: Plan to have insertive anal intercourse with the study partner with Advantage 24 applied to the glans of the penis, and using non-N-9 lubricant and condoms, at the couple's usual frequency (at least 3 times per week). Agree to apply the specified amount of Advantage 24 daily to the penis.
Study Centers
These are the hospitals, clinics, or research facilities where the trial is being conducted. You can find the location closest to you and its status.This study has 1 location