DIETFITSDo Insulin Secretion or Genotype Pattern Predict Low Fat vs Low Carb Weight Loss Success?

Date de début de l'étude : 1 janvier 2013

Inclusion Criteria: Age: > 18 years of age Women: Pre-menopausal (self-report) and <50 years of age Men: <50 years of age BMI (body mass index): 27-40 kg/m2 (need to lose >10% body weight to achieve healthy BMI) Body weight stable for the last two months, and not actively on a weight loss plan No plans to move from the area over the next two years Available and able to participate in the evaluations and intervention for the study period Willing to accept random assignment To enhance study generalizability, people on medications not noted below as specific exclusions can participate if they have been stable on such medications for at least three months Ability and willingness to give written informed No known active psychiatric illness Exclusion Criteria: Subjects with the following conditions will be excluded (determined by self-report): Pregnant, lactating, within 6 months post-partum, or planning to become pregnant in the next 2 years Diabetes (type 1 and 2) or history of gestational diabetes or on hypoglycemic medications for any other indication Prevalent diseases: Malabsorption, renal or liver disease, active neoplasms, recent myocardial infarction (<6 months)(patient self-report and, if available, review of labs from primary care provider) Smokers (because of effect on weight and lipids) History of serious arrhythmias, or cerebrovascular disease Uncontrolled hyper- or hypothyroidism (TSH not within normal limits) Medications: Lipid lowering, antihypertensive medications, and those known to affect weight/energy expenditure Excessive alcohol intake (self-reported, >3 drinks/day) Musculoskeletal disorders precluding regular physical activity Unable to follow either of the two study diets for reasons of food allergies or other (e.g., vegan) Currently under psychiatric care, or taking psychiatric medications Inability to communicate effectively with study personnel