A Prospective, Randomized, Double Blind, Comparative-effectiveness Study Comparing Perioperative Administration of Oral Versus Intravenous Acetaminophen for Laparoscopic Cholecystectomy

Subjects were enrolled following the listed inclusion and exclusion criteria. Subjects Eligibility Criteria: Inclusion Criteria: Male and female patients ASA I - III . 18 years of age and older Exclusion Criteria: Chronic pain syndromes (pain symptoms lasting greater than 3 months), previous abdominal surgery Chronic home narcotic use (patient-reported narcotic use for greater than 3 months) Previous Bowel resection, colon surgery, stomach surgery . Liver disease (AST or ALT greater than 3 times upper limit of normal), on labs closest to surgical date or within 6 months prior to surgery Severe renal disease (creatinine clearance less than 30 mL/min), on labs closest to surgical date or within 6 months prior to surgery Open or emergency surgery (non-scheduled surgery, surgery that must be performed within 6 hours for this particular surgery) Prior NSAIDS (Non-Steroid Anti-inflammatory Drugs) including COX-2 agents use within the last 24 hours Use of intraoperative NSAIDs Contraindication to study drug (including allergic reaction or hypersensitivity to acetaminophen or any of its components; Taking a medication with known interactions with acetaminophen Taking chronic oral acetaminophen, greater than 6 months on a daily basis at a dose greater than 3000mg/day Pregnancy Current or past alcohol abuse (within the past 2 years)