PPBPre-recovery Percutaneous Biopsy of Livers in Neurological Death Organ Donors - A Pilot Study

Date de début de l'étude : 1 février 2013

Inclusion Criteria: Neurological death donors in whom brain death determination is imminent First person or next of kin consent for research becomes available High risk donor, as defined by the following criteria i) Known liver disease ii) Hepatitis BsAg, BcAb, B DNA, Hepatitis C Ab or Hepatitis C RNA positivity iii) Age >= 50 iv) Any of the following risk factors for fatty liver disease a) BMI >= 30 b) History of Type 2 Diabetes Mellitus c) Ultrasound, Computerized Tomography or other imaging modalities suggesting steatosis v) Any of the following risk factors for chronic liver disease Greater than 2 drinks of alcohol daily currently or in their history Current IV drug use Ultrasound, Computerized Tomography or other imaging modalities suggesting cirrhosis Exclusion Criteria: Donation after cardiac death donors Live organ donors No first person consent and next of kin decline research consent Donors in whom it has been established the liver will not be shared Donors in whom percutaneous liver biopsy has been performed within the past month for any indication and the biopsy results are available and considered reliable. Donor with a contraindication to liver biopsy, including INR > 2, PTT > 75, Platelets < 70,000, history of coagulopathy, current or recent use (within 7 days) of antiplatelet agent such as aspirin or Plavix, and hemodynamic instability defined as a MAP less than 65mmHg. Inability to position donor appropriately for performance of PPB Unavailability of pathology staff to analyze specimen in a timely manner