HULPUROPhase II Clinical Trial to Study the Feasibility and Safety of the Expanded Autologous Mesenchymal Stem Cells Use Derived From Adipose Tissue (ASC) for the Local Feminine Stress Urinary Incontinence

Date de début de l'étude : 1 septembre 2012

Inclusion Criteria: -Signed informed consen -Good general state of health according to the findings of ythe clinical history and the physical examination -Postmenopausal or over 18 years old women taking highly effective contraceptives following the ICH (M3) EMA guide -Women having rejected de rehabilitation treatment or in which the treatment had failed -Genuine or combined stress urinary incontinence diagnosed with at least 1 year of evolution Exclusion Criteria: -Pregnant or lactating women -Active urine infection -Presenting an infravesical obstruction -Alcohol or other addictive substances abuse antecedents in the previous 6 months to the inclusion -Presenting any other malignant neoplasia unless it is a basocellar or a skin epidermoide carcinoma or presents antecedents of malignant tumours, unless they are in a remission phase for the previous 5 years -Cardiopulmonar illness that, in the investigator opinion, could be unstable or could be serious enough to drop the patient from the study -Any kind of medical or psychiatric illness that, in the investigator opinion, could be a reason to exclude the patient from the study -Subjects with congenital or aquired inmunodeficiencies, B and/or C Hepatitis, Tuberculose or Treponema diagnosed at the moment of inclusion -Anesthesic allergy -Major surgery or severe trauma in the previous 6 months -Administration of any drug under experimentation in the present or 3 months before recruitement