Imaging Stimulant and Non Stimulant Treatments for ADHD: A Network Based Approach

Date de début de l'étude : 1 octobre 2012

Inclusion Criteria: General inclusion criteria for subjects with ADHD and healthy controls are: aged 7-17 years; Wechsler Intelligence Scale for Children (WISC) scores ≥ 75; informed consent and assent to study participation. Specific inclusion criteria for youth with ADHD are: diagnosis of ADHD, any subtype, determined by Kiddie Schedule for Affective Disorders and Schizophrenia for School-Aged Children-Present and Lifetime Versions (K-SADS-PL); ADHD Rating Scale-IV-Parent Version: Investigator Administered (ADHD-RSIV) total score ≥ 1.5 SD above age and gender means for subtype Clinical Global Impressions-ADHD-Severity (CGI-S) score > 4; ADHD must be the primary diagnosis and focus of treatment, and the treatments offered in the study must not be contraindicated for the comorbid disorder. Exclusion Criteria: General exclusion criteria are: history of head injury with loss of consciousness or any CNS disease that is likely to affect brain function; diagnosis of autism or pervasive developmental, psychotic, major mood, and Tourette's disorder; alcohol or drug abuse in the past 3 months or a positive urinary toxic screen on initial evaluation; use of psychotropic medication within 2 weeks of the study (8 weeks for fluoxetine); pre-existing medical or psychological condition which precludes being in the scanner (e.g., claustrophobia, morbid obesity); metal in the body that precludes scanning (e.g., braces, metal plate); positive urine pregnancy test. Specific exclusion criteria for the treatment trial include: previous unsuccessful trial of MPH or ATX that was adequately dosed (≥ 1 mg/kg for MPH or 1.0 mg/kg for ATX) and of adequate duration (≥ 4 weeks); abnormal findings on physical exam, or vital signs pulse and blood pressure > 95% of age and gender mean; inability to swallow capsules; weight is < 20 kg or > 85 kg. Specific exclusion criteria for control youth include: no past history or current diagnosis of any psychiatric disorder, determined by the K-SADS-PL interview; ADHD-RS-IV and CBCL scores for each symptom domain ≤ 1 SD of age and gender means.