ENCAPBioavailability and Acceptability of Enteric-Coated Microencapsulated Calcium During Pregnancy: A Randomized Crossover Trial in Bangladesh (Encapsulated Calcium Absorption in Pregnancy)

Date de début de l'étude : 1 février 2013

Inclusion Criteria: Women aged 18 to 30 years Current residence in Dhaka at a fixed address Plan to remain in Dhaka for at least 2 months from date of enrolment Gestational age of 27 completed weeks ± 1 week, estimated based on the recalled first day of the last menstrual period (LMP) Exclusion Criteria: Complicated medical or obstetric history, based on self-report or clinical assessment by physician (e.g., cardiovascular disease, uterine hemorrhage, placenta previa, threatened abortion, hypertension, preeclampsia, multiple gestation, diabetes, renal disease) Higher risk pregnancy based on one or more of the following clinical findings at time of recruitment: Severe anemia (hemoglobin <70 g/L assessed by Hemocue) Proteinuria (≥ 100 mg/dl based on urine dipstick) Glycosuria (≥ 100 mg/dl based on urine dipstick) Hypertension (systolic blood pressure, ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg) Reported use of dietary supplements that contain >500 mg of calcium per day and/or >400 IU (10 mcg) of vitamin D per day Reported use (chewing) of betel leaf, areca nut and lime (together referred to locally as paan) during pregnancy