A Controlled, Randomized, Double-Blind Trial of Sertraline in Patients With Frontal Lobe Dementia (FLD)

Date de début de l'étude : 1 décembre 1997

Characterized as having behavioral manifestations using a standardized neuropsychiatric scale and interview. FLD patients' frontal cognitive sysfunctions characterized using a short neurobehavioral test battery. Patients must be able to be tested and cooperative with the procedures required in this protocol. No contraindications to the use of Sertraline. No medical conditions that can reasonably be expected to subject the patient to unwarranted risk (e.g., cancer) or require frequent changes in medication. Well-controlled medical conditions such as hypertension and diabetes will not be excluded. Patients must not be pregnant or nursing and must be using effective contraception, if still at child-bearing age. No history of prior severe traumatic brain injury or other severe neurologic or psychiatric condition, such as psychosis, stroke, multiple sclerosis, or spinal cord injury. Not using any psychotropic medication which cannot be stopped 4 weeks before the study.