Natural History of Treated Neurocysticercosis and Long-Term Outcomes

Study Description: The purpose of this protocol is to follow participants with cysticercosis during and after completion of treatment, to characterize the disease course during both short- and long-term follow-up, assess biomarkers associated with infection and response to treatment, improve diagnostic assays, and explore host-parasite interactions. Primary Objective: The primary objective is to characterize the biochemical and clinical course of neurocysticercosis (NCC) during and after treatment with long-term follow-up. Secondary Objectives: 1. To develop novel biomarkers associated with active infection 2. To further understand host-parasite interactions, including the inflammatory response 3. Understand the basis for the pleiomorphic clinical manifestations, including the possible contributions of parasite and host genetics 4. Develop a screening paradigm Primary Endpoint: Description of clinical presentation, imaging features, morbidity, response to treatment, and outcomes in all forms of NCC. Secondary Endpoints: 1. Central and peripheral immune cell phenotyping and cytokine measurements 2. Including, but not limited to bulk transcriptomics, referral to study for participant whole genome sequencing, cestode-specific genome sequencing 3. Biobanking cerebrospinal fluid (CSF), serum, plasma, urine 4. Test known and novel biomarkers, serologic responses in the pre-clinical stage of neurocysticercosis, correlate findings with imaging.