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To evaluate the safety and efficacy of liposomal doxorubicin hydrochloride ( DOX-SL ) alone or in combination with bleomycin and vincristine in the long-term treatment of AIDS-related Kaposi's sarcoma. To determine whether the 3-drug combination enhances progression-free survival and quality of life. Liposomal formulations of chemotherapeutic agents increase drug accumulation in tumors, which permits disease palliation at relatively low doses and thus decreases some of the dose-limiting toxicity. Multi-agent therapy is considered to be more effective than single-agent therapy; therefore, DOX-SL will be combined with bleomycin and vincristine. Liposomal formulations of chemotherapeutic agents increase drug accumulation in tumors, which permits disease palliation at relatively low doses and thus decreases some of the dose-limiting toxicity. Multi-agent therapy is considered to be more effective than single-agent therapy; therefore, DOX-SL will be combined with bleomycin and vincristine. Patients are randomized to receive intravenous DOX-SL alone or in combination with vincristine/bleomycin every 2 weeks. Filgrastim ( granulocyte colony-stimulating factor; G-CSF ) may be given as needed for neutropenia. AS PER AMENDMENT 11/7/96: Based on interim review data, it is recommended that subjects receiving DOX-SL plus vincristine/bleomycin have vincristine/bleomycin discontinued and receive DOX-SL alone unless, in the opinion of the treating physician, they are benefitting from the DOX-SL plus vincristine/bleomycin regimen.
Inclusion Criteria Concurrent Medication: Allowed: * G-CSF. * Licensed or Treatment IND-approved antiretrovirals ( AZT, ddI, ddC, d4T ). * PCP prophylaxis (required if CD4 count \< 200 cells/mm3). * Chemoprophylaxis or maintenance for bacterial infections, candidiasis, MAC, and herpes simplex. * Up to 14 days of metronidazole. * Recombinant erythropoietin. Patients must have: * Documented HIV infection. * Advanced stage Kaposi's sarcoma. * No active acute opportunistic infection. Exclusion Criteria Co-existing Condition: Patients with the following symptoms or conditions are excluded: * Significant pulmonary insufficiency (unless due to pulmonary KS). * Significant cardiac insufficiency. * Other active malignancies except for basal or squamous cell carcinoma of the skin or in situ cervical cancer. * Grade 2 or worse peripheral neuropathy. * Altered mental status that prevents informed consent. * Active Mycobacterium tuberculosis. * Hypersensitivity or allergic reaction to any study drugs or E. coli-derived medications such as filgrastim (G-CSF). Concurrent Medication: Excluded: * GM-CSF. * Drugs associated with peripheral neuropathy (other than approved antiretrovirals and vincristine). * Multi-drug therapy for active Mycobacterium tuberculosis (although isoniazid and pyridoxine is allowed as treatment for a positive PPD, with permission of study chair). Concurrent Treatment: Excluded: * Radiation therapy to study marker lesions. Patients with the following prior condition are excluded: * Neuropsychiatric history. Prior Medication: Excluded: * Any anti-KS therapy within 21 days prior to study entry. * Prior systemic therapy with any anthracycline (including liposomal anthracyclines), vincristine, or bleomycin. * Any investigational drug (other than those available through Treatment IND and used for FDA-sanctioned purposes) within 14 days prior to study entry. PER AMENDMENT 11/29/95: * No more than 2 cycles of any systemic chemotherapy for Kaposi's sarcoma.