A Phase I Study of AZT and Human Interferon Alpha (Recombinant Alpha-2A and Lymphoblastoid) in the Treatment of AIDS-Associated Kaposi's Sarcoma

Inclusion Criteria Patients must have biopsy-proven AIDS-associated Kaposi's sarcoma. Evidence of HIV infection as manifested by a positive antibody test. Exclusion Criteria Active drug or alcohol abuse. Co-existing Condition: Excluded are patients with: Active opportunistic infections requiring ongoing therapy. Excluded within 90 days of study entry: Must be off therapy for Pneumocystis carinii pneumonia (PCP) unless recovered. Clinically significant cardiac disease, including a history of myocardial infarction or arrhythmia. Concurrent neoplasms other than basal cell carcinoma of the skin. Known hypersensitivity to polymycin B or neomycin. Excluded are patients with: Active opportunistic infections requiring ongoing therapy. Excluded within 90 days of study entry: Must be off therapy for Pneumocystis carinii pneumonia (PCP) unless recovered. Clinically significant cardiac disease, including a history of myocardial infarction or arrhythmia. Concurrent neoplasms other than basal cell carcinoma of the skin. Known hypersensitivity to polymycin B or neomycin. Prior Medication: Excluded: Interferon. Zidovudine (AZT). Excluded within 30 days of study entry: Any biologic modifiers, corticosteroids, cytotoxic chemotherapeutic agents. Other drugs which can cause neutropenia or significant nephrotoxicity. Rifampin or rifampin derivatives, or systemic anti-infectives. Excluded within 90 days of study entry: Other antiviral agents. A history of Pneumocystis carinii pneumonia (PCP) completed treatment. Prior Treatment: Excluded within 30 days of study entry: Radiation therapy.