Development and Validation of Test for Gastro-esophageal Reflux and Aspiration

Fecha de inicio: 1 de julio de 2015

Inclusion Criteria: Healthy participants Adult non-smokers Females only - negative urine pregnancy test Lung transplant patients Adult patients awaiting (or recently undergone) - lung transplant Evidence of gastro-esophageal reflux with probable recurrent aspiration Females only - negative urine pregnancy test Idiopathic pulmonary fibrosis patients Adult patients currently enrolled in on-going University of California, San Francisco study of prevalence of recurrent GER with aspiration in idiopathic pulmonary fibrosis Evidence of gastro-esophageal reflux with probable recurrent aspiration Females only - negative urine pregnancy test Exclusion criteria: Healthy participants History of dysphagia GER Recurrent cough Asthma Pneumonia after childhood Sleep impairment Use of drugs or alcohol impairing consciousness Impaired gag reflex on physical examination Any other significant medical illness (e.g., morbid obesity, diabetes, neurologic disease, etc.) that in the opinion of the investigator could affect the clinical features measured, responses to the therapies to be given in this study, or risks of participating in the study Greater than 5 pack years lifetime smoking history History of intolerance or allergy to cromolyn sodium Lung transplant patients History of intolerance or allergy to cromolyn sodium History of Nissen fundoplication IPF patients History of intolerance or allergy to cromolyn sodium History of Nissen fundoplication