PETImpacto del Ejercicio en los Síntomas y la Liberación de Dopamina en la Enfermedad de Parkinson

Fecha de inicio: 1 de abril de 2013

Inclusion Criteria: Idiopathic PD according to UK Brain Bank criteria (modified to permit inclusion of subjects with a family history) Ages 40-70 Mild to moderate Parkinsonism (Hoehn & Yahr stages I-III) Exclusion Criteria: General exclusion criteria will include: more than 120 minutes per week of activities >3 MET or a score exceeding 4 on the "Baseline Exercise Screening Tool" (Appendix, Fig. 1); atypical Parkinson syndrome (progressive supranuclear palsy, multiple system atrophy, drug-induced etc.); significant osteoporosis or arthritis; other neurological disease (e.g. myopathy); self-reports claustrophobia; history of cancer within 5 years of study participation; high dose of radiation from other procedures within the year; taking rasagiline or selegiline for PD therapy; diabetic; not able to tolerate being off PD medication for up to 24 hours; BMI of 35 or more; and a female subject who is breast-feeding or pregnant. Exclusion criteria for MRI scanning and magnetic stimulation from rTMS scanning includes: artificial heart valve; brain aneurysm clip; electrical stimulator for nerves or bones; ear or eye implant; implanted drug infusion pump; coil, catheter, or filter in any blood vessel; orthopedic hardware (artificial joint, plate, screws); other metallic prostheses; shrapnel, bullets, or other metal fragments; surgery or tattoos (including tattooed eyeliner) in the last six weeks; have a cardiac pacemaker, wires or defibrillator; have had an injury where a piece of metal lodged in your eye or orbit; have a ferromagnetic aneurysm clip; and have a history of seizures. Subjects may be excluded following study enrollment if they meet any of the following exclusion criteria: significant cognitive impairment (Montreal Cognitive Assessment score < 24) or depression (Beck Depression Inventory score > 18); significant or unstable cardiovascular or respiratory disease - all subjects will undergo a screening exercise bicycle stress test; or failure to comply with the exercise or yoga/stretching intervention program, including missing 5 sessions or missing three sessions in a row.