Relationship of Purine Metabolism Enzyme Single-Nucleotide Polymorphisms to Uric Acid Production and Response to Xanthine Oxidase Inhibitors

Fecha de inicio: 1 de diciembre de 2012

Inclusion Criteria: The study will be open to all adults over age 18 years of age who satisfy at least one of the conditions below: Have asymptomatic hyperuricemia (serum uric acid level > 7.0 mg/dL) on at least 2 separate occasions, Clinical diagnosis of gout, Have neither asymptomatic hyperuricemia or gout but will serve as part of the control group (approximate age/gender matched control) Exclusion Criteria: To best isolate the relationship between purine enzyme SNPs to hyperuricemia or gout and its treatment, factors which could elevate the serum uric acid level independent of protein function need to be excluded. Specifically, patients who are "overproducers" of serum uric acid will be excluded: Have a myeloproliferative disorder (hematologic malignancy such as leukemia or lymphoma) Are actively receiving therapy for any neoplasia (aside from non-melanoma skin cacner) Have greater than 5% of skin involvement from psoriasis Have a known history of xanthinuria Consume more than 14 drinks per week of alcoholic beverages Patients that are pregnant or nursing will not be enrolled. Patients to be enrolled in the control group will also be excluded from enrollment if they have any of the conditions above.