Multi-Modal fMRI/NIRS for Estimation of CMRO2 for Neuroimaging Studies of Drug Abuse and Psychiatric Illness Problems

Fecha de inicio: 1 de marzo de 2012

Inclusion Criteria: Male 18 to 40 years old Physically healthy by self-report Exclusion Criteria: Diagnosis of current drug abuse/dependence, including nicotine, as assessed by DSM-IV criteria Current diagnosis of Axis I disorder using DSM-IV criteria, or any Axis I disorder within past 5 years Current daily use of antipsychotic, antidepressant, or other psychoactive prescription drug, as well as daily use of non-prescription drugs Life threatening or unstable medical illness, or one that can create marked change in mental state Heavy caffeine use (greater than 300 mg on a regular, daily basis) History of seizure disorder Subjects that report any history or current major medical illness (cardiovascular, pulmonary, psychiatric, or neurological disorders) Subjects who have metal in their body or suffer from claustrophobia cannot participate in this research study. Additional MR exclusion criteria may include people with: Cardiac pacemakers Metal clips on blood vessels (also called stents) Artificial heart valves Artificial arms, hands, legs, etc. Brain stimulator devices Implanted drug pumps Ear implants Eye implants or known metal fragments in eyes Exposure to shrapnel or metal filings (wounded in military combat, sheet metal workers, welders, and others) Other metallic surgical hardware in vital areas Certain tattoos with metallic ink (subjects are asked to inform research staff if they have a tattoo) Metal Containing Intrauterine Devices (IUDs). Certain transdermal (skin) patches such as Transderm Scop (scopolamine for motion sickness).