Residual Platelet Activity Despite Aspirin Utilization in Patients With Non ST Elevation Acute Coronary Syndromes: Comparison Between the Acute and Chronic Phases

Fecha de inicio: 1 de diciembre de 2009

Inclusion Criteria: Age ≥ 18 years Confirmed diagnosis of acute coronary syndrome without ST segment elevation, in the first 48 hours after the onset of the clinical symptoms Regular use of aspirin for at least seven days. Exclusion Criteria: Previous use, in the last 7 days, of another antiplatelet agent than aspirin Use of antivitamin K in the last 3 weeks Hemoglobin < 10g/dL and / or hematocrit < 30% or > 50%, platelets count < 100.000/mm3 or > 500.000/mm3, creatinine clearance < 30 mL / minute Killip class III or IV Need for vasopressor or inotropic parenteral medication at inclusion in the study Percutaneous coronary intervention within 30 days or CABG in the last 90 days prior to study entry Current malignancy Hematologic diseases Refusal to sign the inform consent form Unable to attend the second visit (follow-up) for any reason except for death