RESECTRandomized, Prospective, Multicenter Blinding Singles With Arm A and Arm B Innovative Strategy Strategy Conventional

Fecha de inicio: 1 de febrero de 2013

Inclusion Criteria: Age greater than 18 years with no upper age limit Competent adult patient. Patient affiliated to the National Health Insurance. Patient with an intra-cerebral supra-tentorial hemispheric, newly diagnosed and previously untreated, which MRI characteristics are suggestive of a glioblastoma. Indication for surgical treatment by excision. Brain tumor location distant from critical functional areas allowing a wide resection of contrast enhancement on imaging, the a priori character completely resectable has been validated by an evaluation committee composed of three surgeons No-cons contain medical surgery, ASA score below 4. Patient eligible for further treatment by radiotherapy and concurrent chemotherapy followed by adjuvant chemotherapy according to the so called Stupp scheme (standard protocol of adjuvant chemoradiotherapy) Negative pregnancy test for women of childbearing age. Exclusion Criteria: Contraindications to performing an MRI (pacemaker). Glioblastoma known and previously treated with surgery, radiotherapy and / or chemotherapy. History of cancer. Anatomical Location of the tumor-cons indicating a wide excision, neurosurgeon at the discretion of medical officer participating center. Location tumor in the brain stem, the middle line, the basal ganglia and the posterior cranial fossa. Patient with cons-indication to the achievement of further treatment with radiotherapy and concurrent chemotherapy followed by adjuvant chemotherapy according to the scheme proposed by Stupp. (1) Patients with porphyria, renal insufficiency (creatinine> 177 μmolL), liver insufficency(gamma glutamyl transpeptidase> 100 U / L, prothrombin time <60%, bilirubin> 51μmol / L). Patient refused to sign an informed consent form. Ongoing participation of the patient to another clinical trial.