HULPOFTPhase IIa Clinical Trial to Study the Feasability and Security of the Expanded Autologous Stem Cells (ASC) From Lipoaspirate in the Bilateral Limbic Associated Keratopathy Treatment

Fecha de inicio: 1 de febrero de 2013

Inclusion Criteria: -Signed informed consent -Previously diagnosed bilateral limbic obstruction -Men and women over 18 years old. Good general state of health according to the findings of the clinical history and the physical examination -Suffering chronic keratopathy accomplishing the following criteria: Confirmed limbic obstruction with an impression cytology Repeated usual treatment failure for this pathology Exclusion Criteria: -Having suffered a neoplasia in the previous 5 years -Local anesthesia allergies -Patients having participate in any other study in the previous 90 days to the inclusion -Patients on medication with tacrolimus or cyclosporine in the 4 previous week to the cellular therapy -Any medical or psychiatric illness that, in the investigator opinion, could suppose a reason for the study exclusion -Patients with any type of medical or psychiatric disease which, in the opinion of the investigator, could be grounds for exclusion from study -Patients with congenital or acquired immunodeficiencies. HIV, HBV, HCV or treponema infection, whether active or latent -Patients who have suffering major surgery or severe trauma in the prior 6 months -Pregnant or breastfeeding women