Exploring Occupancy of Dopamine D3 Receptor by Buspirone in Humans Using PET

Fecha de inicio: 1 de octubre de 2012

Inclusion Criteria: - 19 years or older Exclusion Criteria: Medical condition including cardiovascular, renal, hepatic or cerebrovascular diseases History of or current neurological illnesses including seizure disorders, migraine, multiple sclerosis, movement disorders, head trauma, CVA or CNS tumor, - Present or past psychiatric condition including mood, anxiety, psychotic disorders and substance abuse and/or dependence. Condition that precludes use of buspirone or that will interfere with participation in the present study (such as hypersensitive to buspirone hydrochloride). Pregnancy or breastfeeding. Presence of metal objects in the body or implanted electronic devices, that preclude safe MR scanning. Claustrophobia. Current use or use during the previous month of medication that may affect the CNS, including monoamine oxidase inhibitor (MAOI) or positive during drug screening for drugs of abuse or any medication that could increase the risk of buspirone administration. Exposure to radiation in the last 12 month exceeding permissible limit for subjects participating in research.