A Randomized, Double-blind 52-week Study to Evaluate the Safety and Efficacy of an LCZ696 Regimen Compared to an Olmesartan Regimen on Arterial Stiffness Through Assessment of Central Blood Pressure in Elderly Patients With Hypertension

LCZ696

LCZ696 matching placebo

Olmesartan matching placebo

amlodipine

hydrochlorothiazide

Olmesartan

LCZ696 matching placebo

amlodipine

hydrochlorothiazide

Change From Baseline in Mean Central Aortic Systolic Pressure (CASP) at 12 Weeks

Change From Baseline in Mean Central Pulse (CPP) Pressure

Change From Baseline in Mean Pulse Wave Velocity (PWV)

Change From Baseline in Mean Central Aortic Systolic Pressure (CASP) at 52 Weeks

Change From Baseline in Mean Sitting Systolic Blood Pressure (msSBP)

Change From Baseline in Mean Sitting Diastolic Blood Pressure (msDBP)

Change From Baseline in Mean Sitting Pulse Pressure (msPP)

Change From Baseline in Mean Arterial Pressure (MAP)

Change From Baseline in Mean 24-hour Systolic Blood Pressure (maSBP)

Change From Baseline in Mean 24-hour Diastolic Blood Pressure (maDBP)

Change From Baseline in Mean 24-hour Ambulatory Pulse Pressure (maPP)