Dem@CareEcological Assessment of Autonomy and Apathy in Alzheimer Patients at Mild and Moderate Stages, as Welle as in Healthy Control Particpants

Fecha de inicio: 25 de junio de 2012

Subjects control Inclusion criteria Male or Female ≥ 65 years Subjects were not accompanied by an Alzheimer subject recruited for the study; Subjects showing no locomotor disability; Subjects with no cognitive impairment overall with a score> 27 on the MMSE. Special cases: people with no schooling aged 50 to 79 years we take a MMSE> 22/30 and for over 80 years a MMSE> 21/30 - by the standards of Kalafat, 2003) (Folstein, Folstein et al. 1975), or arguments in favor of the following diagnosis: probable Alzheimer's disease according to the criteria of the NINCDS-ADRDA and / or major depressive episode according to DSM-IV-R; Subjects receiving a social security system; Signature of informed consent. Exclusion Criteria Failure to perform the protocol due to a mobility impairment; Prescription of a new psychotropic medication (hypnotic, anxiolytic, antidepressant, antipsychotic) in the week preceding the assessment; Patients implanted with a pacemaker; Patient Trust under curatorship or judicial protection; Detainees (administrative or judicial). Predementia / MCI Patients Inclusion criteria Men or women ≥ 65 years. Subjects with a diagnosis of MCI according to the criteria of the National Institute on Ageing and Alzheimer's Association group (Albert MS, 2011, see Appendix B), or Alzheimer's disease stage prédementiel (B. Dubois, 2010; see Appendix C) Subjects with a score of 0 to items of "tremors" and "muscle stiffness" of the UPDRS III Subjects with no criteria for major depressive episode according to DSM IV-R; Subjects receiving a social security system; Signature of informed consent. Exclusion Criteria Failure to pass neuropsychological testing because of a sensory or motor deficit; Prescription of a new psychotropic medication (hypnotic, anxiolytic, antidepressant, antipsychotic) in the week preceding the assessment; Patients implanted with a pacemaker; Patient Trust under curatorship or judicial protection. dementia subjects Inclusion criteria Men and women older than 65 years Subjects with a diagnosis of Alzheimer's disease according to NINCDS-ADRDA (McKhann, Drachman et al. 1984) or Alzheimer's typical or atypical (B. Dubois et al. 2007) MMSE score ≥ 16 Subjects with a score of 0 to items of "tremors" and "muscle stiffness" of the UPDRS III Subjects with no criteria for major depressive episode according to DSM IV-R; Subjects receiving drug treatment by acetylcholinesterase inhibitor or memantine in standard dose and stable for at least 3 months; Subjects receiving a social security system; Signature of informed consent. Exclusion Criteria Failure to pass neuropsychological testing because of a sensory or motor deficit; Prescription of psychotropic medication (hypnotic, anxiolytic, antidepressant, antipsychotic) in the week preceding the assessment; Patients implanted with a pacemaker Patient Trust under curatorship or judicial protection.