Weight Loss Diet Study: Low Carbohydrate vs. Low Fat and Insulin Resistance Status

Fecha de inicio: 1 de abril de 2012

Inclusion Criteria: Age: > or = 18 years of age Women: Pre-menopausal (self-report) and <50 years of age Men: <50 years of age Race/Ethnicity: All BMI (body mass index): 28-40 kg/m2 (need to lose >10% body weight to achieve healthy BMI) Body weight stable for the last two months, and not actively on a weight loss plan No plans to move from the area over the next 14 months Available and able to participate in the evaluations and intervention for the study period Willing to accept random assignment To enhance study generalizability, people on medications not noted below as specific exclusions can participate if they have been stable on such medications for at least three months Ability and willingness to give written informed consent No known active psychiatric illness Exclusion Criteria: Pregnant, lactating, within 6 months post-partum, or planning to become pregnant in the next 12 months; no menstruation for the previous 12 months Diabetes (type 1 and 2) or history of gestational diabetes or on hypoglycemic medications for any other indication Prevalent diseases: Malabsorption, renal or liver disease, active neoplasms, recent myocardial infarction, hypertension (except for those stable on hypertensive medications) (<6 months) (patient self-report and, if available, review of labs from primary care provider) Smokers (because of effect on weight and lipids) History of serious arrhythmias, or cerebrovascular disease Uncontrolled hyper- or hypothyroidism (TSH not within normal limits) Medications: Lipid lowering, diabetes medications, and those known to affect weight/energy expenditure Excessive alcohol intake (self-reported, >3 drinks/day)