Study of Heparin Prophylaxis of Hereditary Angioedema Exacerbations
heparin
Enfermedades de inmunodeficiencia primaria+11
+ Enfermedades Hereditarias de Deficiencia del Complemento
+ Enfermedades Cardiovasculares
Estudio de Tratamiento
Resumen
Fecha de inicio: 1 de enero de 1994
Fecha en la que se inscribió al primer participante.PROTOCOL OUTLINE: This is a randomized, double blind, placebo controlled, 3 way crossover study. All patients complete diary cards for the first month of the study in order to determine compliance in providing a daily record of symptoms and medication taken. All compliant patients receive subcutaneously injected heparin twice daily, inhaled heparin daily, or matched saline placebo in a random order. Each of the three drug administration periods lasts 2 months, for a total of 6 months of treatment. Patients who have a flare in disease activity that requires hospitalization are terminated from that drug administration period of the study. Patients are followed biweekly during the first month and again at the end of the second month for each of the three 2 month drug administration periods. Completion date provided represents the completion date of the grant per OOPD records
Protocolo
Esta sección proporciona detalles del plan del estudio, incluyendo cómo está diseñado y qué se está evaluando.Se reclutarán 24 pacientes
Número total de participantes que el ensayo clínico espera reclutar.Estudio de Tratamiento
Elegibilidad
Los investigadores buscan pacientes que cumplan ciertos criterios, conocidos como criterios de elegibilidad: estado general de salud o tratamientos previos.Cualquier sexo
Sexo biológico de los participantes elegibles para inscribirse.A partir de 8 años
Rango de edades de los participantes que pueden unirse al estudio.Voluntarios sanos no permitidos
Indica si personas sanas, sin la condición que se estudia, pueden participar.Condiciones
Patología
Criterios
PROTOCOL ENTRY CRITERIA: --Disease Characteristics-- Confirmed diagnosis of hereditary angioedema (HAE) based upon C4 antigenic level, positive family history, and C1 inhibitor (C1INH) antigenic level (Type I HAE) or functional level (Type II HAE) Functional C1 within normal levels if diagnosis of acquired C1INH is possible Negative family history will not exclude as long as patient meets all other criteria, has normal C1 level, and has no evidence of acquired C1INH deficiency History of symptoms of HAE including episodic swelling, abdominal pain, and/or respiratory difficulty Experiencing a minimum of 1-2 HAE episodes within 6 weeks --Prior/Concurrent Therapy-- Endocrine therapy: Anabolic steroids allowed as long as dose has not been changed in at least 30 days Other: No concurrent and at least 1 week since prior aspirin, nonsteroidal antiinflammatory agents, dipyridamole, Coumadin-like drugs, or any other medication having an effect on coagulation or platelets --Patient Characteristics-- Hematopoietic: No clinically significant history of hematologic disease Hepatic: No clinically significant history of hepatic disease Renal: No clinically significant history of renal disease Cardiovascular: No clinically significant history of cardiac disease or hypertension Pulmonary: No clinically significant history of pulmonary disease Other: No contraindication to the use of inhaled or subcutaneous heparin No drug allergy that would interfere with the study No clinically significant history of: Malignancy Diabetes mellitus Neurologic disease Immunologic disease Bleeding disorder Infirmity No history of drug abuse, alcoholism, psychosis, or other psychological/psychiatric disorder